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Scientists have made a major ____ in cancer research.

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break-in    breakthrough    breakup    breakdown  
symbols   signs   marks   signals  
broken through    worked out      fallen out    got round  
had been studying    have been studying    have studied    are studying  
promotion  advance   accession  progress  
breakthrough; what    breakdown; which    breakup; that    breakthrough; which  
principle  breakthrough  conclusion  introduction  
broken through    worked out    fallen out    got round  
who    which    what    when  
made up    put forward    applied for    put up  
broken through    worked out    fallen out    got round  
break-in    breakthrough    breakup    breakdown  
make    to make    made    making  
figure out; has made    will figure out; will make    figure out; will have made    will figure out; will be making  
make   making   makes   made  
in which case    for which reason    which    what  

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