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— is your pen? —It's blue and white. A. How B. What color C. What D. What's color
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FabienCousteauwasbornwithdeeplovefortheocean.Hisgrandfatherandhisfatherwereoceanexplorersanddocumentaryfilmmakers.Fabienspenthisearlyyearsonhisgrandfather'sships.TodayFabienfollowsinhisfamily'sfootstepstoprotecttheplanet'sendangeredoceanlife.Withhisvastknowledgeandexperiencehetriestostrikeabalancebetweenenvironmentalproblemsandmarketeconomies. Fabieniswellknownforhisstudyofsharks.During2000﹣2002hecreatedaTVspecialcalledAttackoftheMysterySharkbasedonthesharkattacksthatoccurredalongtheNewJerseyshorelineinthesummerof1916.Thenin2003﹣2006withthehelpofalargecrewFabiencreatedasharksubmarine潜艇thatenabledhimtoputhimselfinsidethesharkworldprovidingpeoplewitharareviewofthemysteriousandoftenmisunderstoodcreatures. Forthenextfouryears2006﹣2010FabienwaspartofaseriescalledOceanAdventureswhichofferedararelookintosomeofthemostfantasticoceanspecies物种andenvironments. In2010FabienstartedPlantAFishanonprofitprojectforchildrentohelprestorelocalwaterecosystemsbyreplantingkeyoceanspecies.Savetheworldonefishatatime.Theprojectisstillinprogressnowanditsfinalgoalistoplant1billionfishworldwide. FromJune1toJuly22014Fabienandhisteamspent31daysunderwatertoresearchhowclimatechangeandpollutionareaffectingtheoceans.Fabien'sMission31brokenewgroundbygoingdeeperlongerandfurtherexposing显露theworldtotheadventureandthemystique神秘ofwhatliesbeneath. FabieniscurrentlyworkingonadocumentaryfilmabouttheadventuresofMission31aswellasbuildinganOceanLearningCentertoprovidechildrenaroundtheworldwiththeopportunitytolearnaboutoceansandengagewithoceanexplorersdirectlythroughsocialmedia. 1WhatisNotFabien'sjob? A.Oceanexplorer B.Documentaryfilmmaker C.Environmentalist D.Mediamanager 2HowisParagraph2developed? A.Byprovidingfacts. B.Byofferinganalyses. C.Bymakingcomparisons. D.Bydrawingconclusions. 3Wecanlearnfromthetextthat. A.Fabien'sPlantAFishprojecthasalreadyachieveditsfinalgoal B.Fabien'sMission31broketherecordsofformeroceanexplorations C.Fabien'sTVspecialaboutsharksisbasedonhischildhoodexperiences D.IttookFabienfouryearstoproduceOceanAdventuresallonhisown 4Inwhichpartofawebsitecanwereadthetext? A.ModernTechnology. B.SpaceExploration. C.OutstandingFigures. D.FantasticWildlife.
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Angelman综合征是一种由于患儿脑细胞中UBE3A蛋白含量缺乏导致的神经系统发育性疾病UBE3A蛋白合成受位于15号染色体上的ube3a基因控制.在人体非神经组织细胞中来自母方或父方的ube3a基因都可以正常表达但在正常人脑细胞中的表达却与其来源有关来自母方的ube3a基因可正常表达来自父方的ube3a基因无法表达过程如图所示.请结合上述信息回答问题. 1UBE3A蛋白是“泛素一蛋白酶体系统”的核心组分之一该系统可特异性“标记”p53蛋白并使其降解.由此推测Angelman综合征患儿脑细胞中p53蛋白的积累量比正常者填“多”或“少”.检测p53蛋白可采用的分子检测方法. 2对部分Angelman综合征患儿和正常人的ube3a基因进行测序相应部分碱基序列如图所示. 患者…TCAAGCAACGGAAA… 正常人…TCAAGCAGCGGAAA… 据此判断患儿的致病机理是来自填“父”或“母”方的ube3a基因发生了从而引起基因结构的改变即基因突变. 3在人脑细胞中来自父方的ube3a基因无法表达的原因是. 4ube3a基因和snrpn基因的遗传填“遵循”或“不遵循”自由组合定律判断的依据是.若产生的某个配子中ube3a基因是母方的而snrpn基因是父方的最可能的原因是在减数分裂 时父母双方各一条非姐妹染色单体部分片段发生了. 5经产前诊断发现一个15号染色体为“三体”的受精卵是由正常卵细胞与异常精子受精形成的其中的ube3a基因全部正常.该受精卵可随机丢失一条15号染色体而完成胚胎发育若它丢失了染色体时就可能会发育成Angelman综合征患儿其几率是.不考虑基因突变用分数表示. 6根据题意请提出治疗Angelman综合征的思路①唤醒沉睡的ube3a基因.例如降解反义RNA重新编程父方的snrpn基因等 ②导入正常的ube3a基因进行基因治疗.
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